In the absence of neural activity, BDNF expression can still be activated. The findings shed light on how therapeutic ketamine used has an antidepressant effect and how it works in both the long and short term.
Prozac reduced polyunsaturated fatty acid lipid concentrations in the brains of juvenile macaque monkeys.
Allopregnanolone, a neuroactive steroid used in the treatment of postpartum depression, alters neural communication in the basolateral amygdala, an area of the brain associated with emotion and mood regulation. The drug may alter the network associated…
A new study adds to the growing body of research linking inflammation to depression. Researchers found the molecule histamine directly inhibits the release of serotonin in the brain by attaching to inhibitory receptors on serotonin neurons in mice.
The MeCP2 gene influences ketamine’s behavioral effect and strengthens synapses, leading to an improvement in the drug’s antidepressant effect over time.
Taking SSRI antidepressants does not increase the risk of developmental delays or autism in children, a new study reports. However, there is an increased risk for ASD and developmental delays in children whose mothers suffer from maternal psychiatric d…
Prescribing SSRIs during late childhood to those with genetic risk factors for psychosis can reduce the deterioration of intellectual abilities, a new study reveals. SSRIs appear to have a neuroprotective effect for certain brain areas associated with …
A new study reveals the molecular and cellular mechanisms behind why some people find it harder to stop using antidepressants than others with depression.
Psilocybin, the psychoactive compound found in magic mushrooms, is as effective at treating depression as conventional SSRI antidepressants. Researchers report, that although not significantly significant, early findings reveal those treated with psilo…
A mouse study refutes the common belief that psilocybin’s ability to produce an anti-depressant effect is attributed to the psychedelic experience it creates. Blocking the psychedelic effect did not affect psilocybin’s anti-depressant effects.
SSRI’s, ketamine, and tricyclic antidepressants all bind with TrkB. The findings challenge the roles serotonin and glutamate receptors play in the effects of antidepressant medications.
Decreased activation of the LEF1 gene is more common in bipolar patients who do not respond to lithium.
With the risk of potential for abuse, some new fast-acting antidepressants, like Ketamine, may not be a magic “cure-all” for depression.
A new small scale study reveals the antidepressant fluvoxamine may be a new tool in the fight against COVID-19. Researchers report fluvoxamine reduced the severity of coronavirus symptoms and hospitalizations.
Study reveals a link between people with depression who are prescribed newer antipsychotic medications and higher mortality risk.
Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic e…
Activity of the c-Fos gene begins the increase on the ninth day of exposure to antidepressants. By day 14, mice showed behavioral changes associated with SSRI use. This may explain why suicide rates drop after nine days of treatment, and symptoms of de…
Using patient-derived adult stem cells, researchers found fish oil created an antidepressant response.
Ketamine increases the number of serotonin 1B receptors. Ketamine binds to serotonin 1B receptors, reducing the release of serotonin and increasing the release of dopamine.
The SSRI sertraline (Zoloft), if taken while pregnant, can result in birth defects caused by the drug damaging a cell’s genetic information. Researchers report one potential way to counter the effect is with specific antioxidants.